Consumptive Competition at Polyneuronally Innervated Neuromuscular Junctions

نویسندگان

  • RICHARD R. RIBCHESTER
  • JACQUELINE A. BARRY
چکیده

CONTENTS PAGE Introduction 465 A definition and some general principles 468 Neuromuscular paradigms of neurotrophic competition 471 Innervation of smooth muscle 471 Innervation of skeletal muscle 472 Indirect evidence for spatial competition in skeletal muscle 473 Predictions regarding plasticity of smooth and skeletal muscle innervation 474 Competition versus co-existence of motor nerve terminal boutons 475 Role of activity 475 Role of selective synapse formation and elimination 478 Molecular basis for neuromuscular synaptic competition 478 Diffusible versus fixed molecular resources 478 Are there growth inhibitory factors in skeletal muscle? 480 An 'induced-fit' model of neuromuscular synaptic competition 482 Concluding discussion 484 References 485

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The regulation of synaptic strength within motor units of the frog cutaneous pectoris muscle.

The physiological properties of frog neuromuscular junctions may vary widely in a single muscle. In order to understand the factors that contribute to this variation, we have studied populations of synapses belonging to individual motor units of the frog cutaneous pectoris muscle. Motor units in this muscle differ widely in twitch strength. A motor axon's synaptic contacts could be found throug...

متن کامل

Precision of reinnervation and synaptic remodeling observed in neuromuscular junctions of living frogs.

Repeated in vivo observations were used to study regenerated nerve terminals in neuromuscular junctions of the adult frog Rana pipiens. Sartorius junctions in living animals were stained with the fluorescent vital dye RH414 and viewed with video fluorescence microscopy. Each junction was observed in the intact muscle and then again 7, 10, and 13 weeks after nerve crush. At 13 weeks, junctions w...

متن کامل

Comment on “Reelin Promotes Peripheral Synapse Elimination

Individual synaptic sites on rodent skeletal muscle fibers are innervated by two or more axons at birth. All inputs but one are then eliminated during the first two postnatal weeks, leaving each muscle fiber singly innervated (1). Quattrocchi et al. (2) reported that polyneuronal innervation of neuromuscular synapses persists well beyond this period in reeler mice (mutant mice lacking Reelin, a...

متن کامل

The relationship of neuromuscular synapse elimination to synaptic degeneration and pathology: insights from WldS and other mutant mice.

Neuromuscular synapse elimination, Wallerian degeneration and peripheral neuropathies are not normally considered as related phenomena. However, recent studies of mutant and transgenic mice, particularly the Wld(S) mutant-in which orthograde degeneration is delayed following axotomy-suggest that re-evaluation of possible links between natural, traumatic and pathogenic regression of synapses may...

متن کامل

Reversing the Outcome of Synapse Elimination at Developing Neuromuscular Junctions In Vivo: Evidence for Synaptic Competition and Its Mechanism

During mammalian development, neuromuscular junctions and some other postsynaptic cells transition from multiple- to single-innervation as synaptic sites are exchanged between different axons. It is unclear whether one axon invades synaptic sites to drive off other inputs or alternatively axons expand their territory in response to sites vacated by other axons. Here we show that soon-to-be-elim...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005